On December 19, 2025, the University of Seville in Spain published a research paper in the journal Cell Metabolism.

This study is the first to demonstrate in mammals that diallyl sulfide (H2S) from garlic can continuously generate hydrogen sulfide through non-enzymatic pathways, extending mouse lifespan by 11.4%—a greater extension than metformin (5.8%)—while improving metabolic, motor, and cognitive functions.

The research team also analyzed human data, finding that among patients with multiple comorbidities, higher plasma protein persulfidation levels were associated with stronger grip strength and lower triglyceride levels, further supporting the potential role of H2S in maintaining human health.

The researchers stated that this study is the first to confirm in mammals that natural compounds from garlic can generate H2S through non-enzymatic pathways, thereby extending lifespan and improving health status. Diallyl sulfide from garlic is safe and readily accessible, providing scientific evidence for developing dietary intervention-based anti-aging strategies.